There is almost no specific information about the content itself in any of these previews. Just a lot of vague commentary that is open to interpretation. The glass can be both half empty and half full.
Vampire: The Masquerade has always been political and, well, not exactly conservative in neither tone nor subject matter. For instance, vampires have historically been a metaphor for both unrestricted sex itself as well as for "unorthodox" forms of sexual behavior. I think some people around here are forgetting that. So yes, there can be openly gay vampires and it would be entirely suitable for this context.
I believe the game isn't going to suddenly sanitize the themes and contents of Bloodlines, but will likely add characters with, for example, various sexual identities and orientations, as implied by the brief character creator talk. Which is fine, I'd say, because players should have the maximum possible amount of choices for the purpose of roleplaying. The world is big enough to contain all sorts of non-playable characters too. Which don't need to be limited to the rather small pool of named characters that existed in Bloodlines.
I've heard that Malkavians are still in the game. They might try to change some of the details of their dialogue and presentation, in order to not unnecessarily offend people with a real life mental illness, but I doubt they'll be impossible to recognize or identify as Malkavian. The writers aren't stupid, to say the least.
